Frank Lampard will return to Stamford Bridge for the first time as a manager on Wednesday night when his Derby County side take on Chelsea in the EFL Cup fourth round.
The Rams are looking to pull off another upset after beating Manchester United in the last round, whereas Chelsea are bidding to continue an impressive unbeaten run under new boss Maurizio Sarri.
Hazard has not featured since picking up a back injury against Manchester United earlier this month, and the Belgian is unlikely to be risked for an EFL Cup game with doubts still lingering over his fitness.
Pedro has been his replacement in the past two games, but he lasted just half an hour against Burnley at the weekend before being taken off due to stomach pains.
Fringe players such as Loftus-Cheek, ex-Nigerian international, Victor Moses, Cesc Fabregas and Andreas Christensen will hope to get a chance to impress from the start, with Sarri expected to make wholesale changes to his side for this match.